titolo
PhD project in Biophysics (Grenoble, France)
target
dipartimento,ppim
ultima_modifica
29-04-2015
testo
"Dynamics of protein aggregates and fibers"
Alongside their native, functional structure, proteins tend to adopt alternative misfolded configurations, including aggregates and amyloid fibers. Whereas the structure and dynamics of native, correctly-folded proteins are well studied and understood, the molecular properties of protein aggregates and fibers are largely unknown. This project aims at obtaining dynamical insights into protein aggregates and fibers by using neutron spectroscopy in combination with MD simulations, SAXS, X-ray diffraction, electron microscopy, FTIR, and CD spectroscopy. The proteins studied will include tau (involved in Alzheimer disease) and gamma-crystallin (involved in human cataract). We have recently shown that the formation of amyloid fibers by the intrinsically disordered protein tau alters the mobility of water molecules on the protein surface. The increased water mobility might serve as a basis for diagnosis of Alzheimer disease. This PhD project is in collaboration with Prof. D. Tobias (UC Irvine, USA).
-- If you are interested, please contact before 15 May 2015 :
(see the attachment, linked below)
Alongside their native, functional structure, proteins tend to adopt alternative misfolded configurations, including aggregates and amyloid fibers. Whereas the structure and dynamics of native, correctly-folded proteins are well studied and understood, the molecular properties of protein aggregates and fibers are largely unknown. This project aims at obtaining dynamical insights into protein aggregates and fibers by using neutron spectroscopy in combination with MD simulations, SAXS, X-ray diffraction, electron microscopy, FTIR, and CD spectroscopy. The proteins studied will include tau (involved in Alzheimer disease) and gamma-crystallin (involved in human cataract). We have recently shown that the formation of amyloid fibers by the intrinsically disordered protein tau alters the mobility of water molecules on the protein surface. The increased water mobility might serve as a basis for diagnosis of Alzheimer disease. This PhD project is in collaboration with Prof. D. Tobias (UC Irvine, USA).
-- If you are interested, please contact before 15 May 2015 :
(see the attachment, linked below)
docsrefs
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