titolo
Colloquia Doctoralia
target
totem,dipartimento,ppim
inizio
Giovedì 02 Maggio 2019 15:00
luogo
Aula F sede di via Pascoli
relatore
Prof. Giancarlo Franzese (Facultat de Fisica & Institute of Nanoscience and Nanotechnology (IN2UB), Universitat de Barcelona - SPAIN)
titoloevento
Multiscale Approach for Hydrated Systems: From Nanomaterials to Perspectives for Brain Cancer Treatments
abstract
The Blood-Brain-Barrier (BBB) is the tight membrane that protects our brain and represents the
major hindrance to the use of chemotherapeutic agents for brain tumors.
Recently it has been showed by in vitro and in vivo studies that the adsorption of a poli poprotein E4 (ApoE4) on lipid nanoparticles (NPs) produces a protein corona that enhances the BBB-crossing, improving brain NP accumulation 3 -fold compared to undecorated particles [1-2]. Therefore, it is possible to increase the ability to cross the BBB for engineered NPs carrying a loose layer of proteins.
Nevertheless, the NP-protein corona composition --and, as a consequence, the
cellular biological response to the NP--
change over time as a consequence of the competition among the plasma proteins once th
e NP is in the blood stream, as we showed [3].
In collaboration with experimental groups, we develop a
multiscale approach for the study of bio-membranes, proteins, NPs and
nanomaterials in aqueous solution oriented to applications to the BBB crossing
for oncological treatments. We model the kinetics of NP interaction with proteins
[3-5], of proteins with water [6-10], and of water with membranes and nanomaterials [11-14], with the aim of finding how to optimize the NP-protein corona formation to cross the BBB.
major hindrance to the use of chemotherapeutic agents for brain tumors.
Recently it has been showed by in vitro and in vivo studies that the adsorption of a poli poprotein E4 (ApoE4) on lipid nanoparticles (NPs) produces a protein corona that enhances the BBB-crossing, improving brain NP accumulation 3 -fold compared to undecorated particles [1-2]. Therefore, it is possible to increase the ability to cross the BBB for engineered NPs carrying a loose layer of proteins.
Nevertheless, the NP-protein corona composition --and, as a consequence, the
cellular biological response to the NP--
change over time as a consequence of the competition among the plasma proteins once th
e NP is in the blood stream, as we showed [3].
In collaboration with experimental groups, we develop a
multiscale approach for the study of bio-membranes, proteins, NPs and
nanomaterials in aqueous solution oriented to applications to the BBB crossing
for oncological treatments. We model the kinetics of NP interaction with proteins
[3-5], of proteins with water [6-10], and of water with membranes and nanomaterials [11-14], with the aim of finding how to optimize the NP-protein corona formation to cross the BBB.
docsrefs
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